Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.
Identifieur interne : 000E85 ( PubMed/Curation ); précédent : 000E84; suivant : 000E86Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.
Auteurs : Fiona J. Mccallum [Australie] ; Kristina E M. Persson [Suède] ; Freya J I. Fowkes [Australie] ; Linda Reiling [Australie] ; Cleopatra K. Mugyenyi [Australie] ; Jack S. Richards [Australie] ; Julie A. Simpson [Australie] ; Thomas N. Williams [Kenya] ; Paul R. Gilson [Australie] ; Anthony N. Hodder [Australie] ; Paul R. Sanders [Australie] ; Robin F. Anders [Australie] ; David L. Narum [États-Unis] ; Chetan Chitnis ; Brendan S. Crabb [Australie] ; Kevin Marsh [Kenya] ; James G. Beeson [Australie]Source :
- Journal of leukocyte biology [ 1938-3673 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiprotozoaires (immunologie), Antigènes de protozoaire (immunologie), Femelle, Humains, Immunité, Immunoglobuline G (immunologie), Jeune adulte, Mâle, Mérozoïtes (immunologie), Paludisme (immunologie), Paludisme (parasitologie), Parasitémie (immunologie), Parasitémie (parasitologie), Production d'anticorps (immunologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
- MESH :
- immunologie : Anticorps antiprotozoaires, Antigènes de protozoaire, Immunoglobuline G, Mérozoïtes, Paludisme, Parasitémie, Production d'anticorps.
- parasitologie : Paludisme, Parasitémie.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Immunité, Jeune adulte, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Protozoan (immunology), Antibody Formation (immunology), Antigens, Protozoan (immunology), Cohort Studies, Female, Humans, Immunity, Immunoglobulin G (immunology), Malaria (immunology), Malaria (parasitology), Male, Merozoites (immunology), Middle Aged, Parasitemia (immunology), Parasitemia (parasitology), Young Adult.
- MESH :
- chemical , immunology : Antibodies, Protozoan, Antigens, Protozoan, Immunoglobulin G.
- immunology : Antibody Formation, Malaria, Merozoites, Parasitemia.
- parasitology : Malaria, Parasitemia.
- Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Immunity, Male, Middle Aged, Young Adult.
Abstract
Antibodies play a key role in acquired human immunity to Plasmodium falciparum (Pf) malaria and target merozoites to reduce or prevent blood-stage replication and the development of disease. Merozoites present a complex array of antigens to the immune system, and currently, there is only a partial understanding of the targets of protective antibodies and how responses to different antigens are acquired and boosted. We hypothesized that there would be differences in the rate of acquisition of antibodies to different antigens and how well they are boosted by infection, which impacts the acquisition of immunity. We examined responses to a range of merozoite antigens in 2 different cohorts of children and adults with different age structures and levels of malaria exposure. Overall, antibodies were associated with age, exposure, and active infection, and the repertoire of responses increased with age and active infection. However, rates of antibody acquisition varied between antigens and different regions within an antigen following exposure to malaria, supporting our hypothesis. Antigen-specific responses could be broadly classified into early response types in which antibodies were acquired early in childhood exposure and late response types that appear to require substantially more exposure for the development of substantial levels. We identified antigen-specific responses that were effectively boosted after recent infection, whereas other responses were not. These findings advance our understanding of the acquisition of human immunity to malaria and are relevant to the development of malaria vaccines targeting merozoite antigens and the selection of antigens for use in malaria surveillance.
DOI: 10.1189/jlb.5MA0716-294R
PubMed: 27837017
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000E88
Links to Exploration step
pubmed:27837017Curation
No country items
Chetan Chitnis<affiliation><nlm:affiliation>Institute Pasteur, Paris, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.</title><author><name sortKey="Mccallum, Fiona J" sort="Mccallum, Fiona J" uniqKey="Mccallum F" first="Fiona J" last="Mccallum">Fiona J. Mccallum</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Persson, Kristina E M" sort="Persson, Kristina E M" uniqKey="Persson K" first="Kristina E M" last="Persson">Kristina E M. Persson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Reiling, Linda" sort="Reiling, Linda" uniqKey="Reiling L" first="Linda" last="Reiling">Linda Reiling</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Mugyenyi, Cleopatra K" sort="Mugyenyi, Cleopatra K" uniqKey="Mugyenyi C" first="Cleopatra K" last="Mugyenyi">Cleopatra K. Mugyenyi</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Jack S" sort="Richards, Jack S" uniqKey="Richards J" first="Jack S" last="Richards">Jack S. Richards</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Simpson, Julie A" sort="Simpson, Julie A" uniqKey="Simpson J" first="Julie A" last="Simpson">Julie A. Simpson</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Williams, Thomas N" sort="Williams, Thomas N" uniqKey="Williams T" first="Thomas N" last="Williams">Thomas N. Williams</name><affiliation wicri:level="1"><nlm:affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi</wicri:regionArea></affiliation></author><author><name sortKey="Gilson, Paul R" sort="Gilson, Paul R" uniqKey="Gilson P" first="Paul R" last="Gilson">Paul R. Gilson</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Hodder, Anthony N" sort="Hodder, Anthony N" uniqKey="Hodder A" first="Anthony N" last="Hodder">Anthony N. Hodder</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Sanders, Paul R" sort="Sanders, Paul R" uniqKey="Sanders P" first="Paul R" last="Sanders">Paul R. Sanders</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Anders, Robin F" sort="Anders, Robin F" uniqKey="Anders R" first="Robin F" last="Anders">Robin F. Anders</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Latrobe University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Latrobe University, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Narum, David L" sort="Narum, David L" uniqKey="Narum D" first="David L" last="Narum">David L. Narum</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name><affiliation><nlm:affiliation>Institute Pasteur, Paris, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation></author><author><name sortKey="Crabb, Brendan S" sort="Crabb, Brendan S" uniqKey="Crabb B" first="Brendan S" last="Crabb">Brendan S. Crabb</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Marsh, Kevin" sort="Marsh, Kevin" uniqKey="Marsh K" first="Kevin" last="Marsh">Kevin Marsh</name><affiliation wicri:level="1"><nlm:affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi</wicri:regionArea></affiliation></author><author><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia; beeson@burnet.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27837017</idno><idno type="pmid">27837017</idno><idno type="doi">10.1189/jlb.5MA0716-294R</idno><idno type="wicri:Area/PubMed/Corpus">000E88</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E88</idno><idno type="wicri:Area/PubMed/Curation">000E85</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.</title><author><name sortKey="Mccallum, Fiona J" sort="Mccallum, Fiona J" uniqKey="Mccallum F" first="Fiona J" last="Mccallum">Fiona J. Mccallum</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Persson, Kristina E M" sort="Persson, Kristina E M" uniqKey="Persson K" first="Kristina E M" last="Persson">Kristina E M. Persson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Reiling, Linda" sort="Reiling, Linda" uniqKey="Reiling L" first="Linda" last="Reiling">Linda Reiling</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Mugyenyi, Cleopatra K" sort="Mugyenyi, Cleopatra K" uniqKey="Mugyenyi C" first="Cleopatra K" last="Mugyenyi">Cleopatra K. Mugyenyi</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Jack S" sort="Richards, Jack S" uniqKey="Richards J" first="Jack S" last="Richards">Jack S. Richards</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Simpson, Julie A" sort="Simpson, Julie A" uniqKey="Simpson J" first="Julie A" last="Simpson">Julie A. Simpson</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Williams, Thomas N" sort="Williams, Thomas N" uniqKey="Williams T" first="Thomas N" last="Williams">Thomas N. Williams</name><affiliation wicri:level="1"><nlm:affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi</wicri:regionArea></affiliation></author><author><name sortKey="Gilson, Paul R" sort="Gilson, Paul R" uniqKey="Gilson P" first="Paul R" last="Gilson">Paul R. Gilson</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Hodder, Anthony N" sort="Hodder, Anthony N" uniqKey="Hodder A" first="Anthony N" last="Hodder">Anthony N. Hodder</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Sanders, Paul R" sort="Sanders, Paul R" uniqKey="Sanders P" first="Paul R" last="Sanders">Paul R. Sanders</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Anders, Robin F" sort="Anders, Robin F" uniqKey="Anders R" first="Robin F" last="Anders">Robin F. Anders</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Latrobe University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Latrobe University, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Narum, David L" sort="Narum, David L" uniqKey="Narum D" first="David L" last="Narum">David L. Narum</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name><affiliation><nlm:affiliation>Institute Pasteur, Paris, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation></author><author><name sortKey="Crabb, Brendan S" sort="Crabb, Brendan S" uniqKey="Crabb B" first="Brendan S" last="Crabb">Brendan S. Crabb</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Marsh, Kevin" sort="Marsh, Kevin" uniqKey="Marsh K" first="Kevin" last="Marsh">Kevin Marsh</name><affiliation wicri:level="1"><nlm:affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi</wicri:regionArea></affiliation></author><author><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><affiliation wicri:level="1"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia; beeson@burnet.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of leukocyte biology</title><idno type="eISSN">1938-3673</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antibodies, Protozoan (immunology)</term><term>Antibody Formation (immunology)</term><term>Antigens, Protozoan (immunology)</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Immunity</term><term>Immunoglobulin G (immunology)</term><term>Malaria (immunology)</term><term>Malaria (parasitology)</term><term>Male</term><term>Merozoites (immunology)</term><term>Middle Aged</term><term>Parasitemia (immunology)</term><term>Parasitemia (parasitology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiprotozoaires (immunologie)</term><term>Antigènes de protozoaire (immunologie)</term><term>Femelle</term><term>Humains</term><term>Immunité</term><term>Immunoglobuline G (immunologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Mérozoïtes (immunologie)</term><term>Paludisme (immunologie)</term><term>Paludisme (parasitologie)</term><term>Parasitémie (immunologie)</term><term>Parasitémie (parasitologie)</term><term>Production d'anticorps (immunologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Protozoan</term><term>Antigens, Protozoan</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiprotozoaires</term><term>Antigènes de protozoaire</term><term>Immunoglobuline G</term><term>Mérozoïtes</term><term>Paludisme</term><term>Parasitémie</term><term>Production d'anticorps</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antibody Formation</term><term>Malaria</term><term>Merozoites</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme</term><term>Parasitémie</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Immunity</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Immunité</term><term>Jeune adulte</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Antibodies play a key role in acquired human immunity to Plasmodium falciparum (Pf) malaria and target merozoites to reduce or prevent blood-stage replication and the development of disease. Merozoites present a complex array of antigens to the immune system, and currently, there is only a partial understanding of the targets of protective antibodies and how responses to different antigens are acquired and boosted. We hypothesized that there would be differences in the rate of acquisition of antibodies to different antigens and how well they are boosted by infection, which impacts the acquisition of immunity. We examined responses to a range of merozoite antigens in 2 different cohorts of children and adults with different age structures and levels of malaria exposure. Overall, antibodies were associated with age, exposure, and active infection, and the repertoire of responses increased with age and active infection. However, rates of antibody acquisition varied between antigens and different regions within an antigen following exposure to malaria, supporting our hypothesis. Antigen-specific responses could be broadly classified into early response types in which antibodies were acquired early in childhood exposure and late response types that appear to require substantially more exposure for the development of substantial levels. We identified antigen-specific responses that were effectively boosted after recent infection, whereas other responses were not. These findings advance our understanding of the acquisition of human immunity to malaria and are relevant to the development of malaria vaccines targeting merozoite antigens and the selection of antigens for use in malaria surveillance.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27837017</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>12</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1938-3673</ISSN><JournalIssue CitedMedium="Internet"><Volume>101</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Journal of leukocyte biology</Title><ISOAbbreviation>J. Leukoc. Biol.</ISOAbbreviation></Journal><ArticleTitle>Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.</ArticleTitle><Pagination><MedlinePgn>913-925</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1189/jlb.5MA0716-294R</ELocationID><Abstract><AbstractText>Antibodies play a key role in acquired human immunity to Plasmodium falciparum (Pf) malaria and target merozoites to reduce or prevent blood-stage replication and the development of disease. Merozoites present a complex array of antigens to the immune system, and currently, there is only a partial understanding of the targets of protective antibodies and how responses to different antigens are acquired and boosted. We hypothesized that there would be differences in the rate of acquisition of antibodies to different antigens and how well they are boosted by infection, which impacts the acquisition of immunity. We examined responses to a range of merozoite antigens in 2 different cohorts of children and adults with different age structures and levels of malaria exposure. Overall, antibodies were associated with age, exposure, and active infection, and the repertoire of responses increased with age and active infection. However, rates of antibody acquisition varied between antigens and different regions within an antigen following exposure to malaria, supporting our hypothesis. Antigen-specific responses could be broadly classified into early response types in which antibodies were acquired early in childhood exposure and late response types that appear to require substantially more exposure for the development of substantial levels. We identified antigen-specific responses that were effectively boosted after recent infection, whereas other responses were not. These findings advance our understanding of the acquisition of human immunity to malaria and are relevant to the development of malaria vaccines targeting merozoite antigens and the selection of antigens for use in malaria surveillance.</AbstractText><CopyrightInformation>© Society for Leukocyte Biology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McCallum</LastName><ForeName>Fiona J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Persson</LastName><ForeName>Kristina E M</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Laboratory Medicine, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fowkes</LastName><ForeName>Freya J I</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departments of Epidemiology and Preventive Medicine and Infectious Diseases, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reiling</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mugyenyi</LastName><ForeName>Cleopatra K</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richards</LastName><ForeName>Jack S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Julie A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>Thomas N</ForeName><Initials>TN</Initials><AffiliationInfo><Affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gilson</LastName><ForeName>Paul R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hodder</LastName><ForeName>Anthony N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanders</LastName><ForeName>Paul R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anders</LastName><ForeName>Robin F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Latrobe University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Narum</LastName><ForeName>David L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chitnis</LastName><ForeName>Chetan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute Pasteur, Paris, France; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crabb</LastName><ForeName>Brendan S</ForeName><Initials>BS</Initials><AffiliationInfo><Affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marsh</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Nuffield Department of Medicine, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beeson</LastName><ForeName>James G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia; beeson@burnet.edu.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Leukoc Biol</MedlineTA><NlmUniqueID>8405628</NlmUniqueID><ISSNLinking>0741-5400</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000913">Antibodies, Protozoan</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000953">Antigens, Protozoan</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1995 Mar;52(3):201-6</RefSource><PMID Version="1">7694959</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2015 Feb;83(2):646-60</RefSource><PMID Version="1">25422270</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2015 Mar 17;42(3):580-90</RefSource><PMID Version="1">25786180</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2005 Dec;73(6):1096-103</RefSource><PMID Version="1">16354819</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(9):e45253</RefSource><PMID Version="1">23028883</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Med. 2014 Jul 01;12:108</RefSource><PMID Version="1">24980799</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2007 Aug;29(8):387-94</RefSource><PMID Version="1">17650180</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2008 May;76(5):2240-8</RefSource><PMID Version="1">18316390</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1995 Aug 1;182(2):409-18</RefSource><PMID Version="1">7629503</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>F1000Prime Rep. 2014 Nov 04;6:100</RefSource><PMID Version="1">25580254</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2009 Jun 29;4(6):e6083</RefSource><PMID Version="1">19562032</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(11):e27705</RefSource><PMID Version="1">22110733</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2012 Nov 15;206(10):1612-21</RefSource><PMID Version="1">22966126</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2007 Nov;77(5):977-83</RefSource><PMID Version="1">17984363</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2013 Feb 1;190(3):1038-47</RefSource><PMID Version="1">23264654</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitology. 2016 Feb;143(2):139-53</RefSource><PMID Version="1">26741253</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2010 Jul 06;7(7):e1000304</RefSource><PMID Version="1">20625549</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Prog Allergy. 1988;41:148-72</RefSource><PMID Version="1">2457214</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2010 Nov 6;376(9752):1566-78</RefSource><PMID Version="1">21035842</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2014 Oct 1;210(7):1123-32</RefSource><PMID Version="1">24737801</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2010 Jan 19;7(1):e1000218</RefSource><PMID Version="1">20098724</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2008 Apr;76(4):1748-55</RefSource><PMID Version="1">18212081</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunol Cell Biol. 2009 Jul;87(5):377-90</RefSource><PMID Version="1">19417768</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2015 Aug 1;212(3):406-15</RefSource><PMID Version="1">25646353</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2015 Nov 1;212(9):1429-38</RefSource><PMID Version="1">25883384</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Proteomics. 2006 Jul;5(7):1286-99</RefSource><PMID Version="1">16603573</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2006 Jan-Feb;28(1-2):51-60</RefSource><PMID Version="1">16438676</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Infect Dis. 2010 Mar 08;10:55</RefSource><PMID Version="1">20205959</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sci Rep. 2016 Feb 11;6:20613</RefSource><PMID Version="1">26865062</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Malar J. 2010 Jun 16;9:169</RefSource><PMID Version="1">20553604</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(7):e41937</RefSource><PMID Version="1">22848665</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Adv Parasitol. 2009;69:299-352</RefSource><PMID Version="1">19622411</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Infect Dis. 2010 Oct 15;51(8):e50-60</RefSource><PMID Version="1">20843207</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Comput Biol. 2007 Dec;3(12):e255</RefSource><PMID Version="1">18166074</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6958-63</RefSource><PMID Version="1">20351286</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2008 Dec;76(12):5721-8</RefSource><PMID Version="1">18809666</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2004 Dec 16;23(5):718-28</RefSource><PMID Version="1">15542195</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEMS Microbiol Rev. 2016 May;40(3):343-72</RefSource><PMID Version="1">26833236</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Trop. 2010 Jun;114(3):138-43</RefSource><PMID Version="1">19481996</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2008 Aug;79(2):185-91</RefSource><PMID Version="1">18689622</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 1997 Aug;65(8):3024-31</RefSource><PMID Version="1">9234749</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2001 May;69(5):3286-94</RefSource><PMID Version="1">11292751</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2004 Aug 1;190(3):439-47</RefSource><PMID Version="1">15243915</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010 Mar 25;5(3):e9871</RefSource><PMID Version="1">20360847</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2009 Aug 1;183(3):2176-82</RefSource><PMID Version="1">19592645</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2005 Dec 2;280(48):40169-76</RefSource><PMID Version="1">16203726</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2006 Feb;74(2):1313-22</RefSource><PMID Version="1">16428781</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Parasitol. 2007 Dec;23(12):575-82</RefSource><PMID Version="1">17988945</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 2004 Mar;34(3):639-48</RefSource><PMID Version="1">14991593</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2005 Jun 1;191(11):1932-9</RefSource><PMID Version="1">15871128</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013 Sep 09;8(9):e74627</RefSource><PMID Version="1">24040299</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 1999 Mar;21(3):133-9</RefSource><PMID Version="1">10205793</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2006 Jan;74(1):257-64</RefSource><PMID Version="1">16368979</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proteomics. 2008 Nov;8(22):4680-94</RefSource><PMID Version="1">18937256</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Med. 2014 Oct 16;12:183</RefSource><PMID Version="1">25319190</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2004 Jun-Jul;26(6-7):265-72</RefSource><PMID Version="1">15541030</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013 Dec 02;8(12):e82246</RefSource><PMID Version="1">24312649</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2010 May 20;6(5):e1000912</RefSource><PMID Version="1">20502681</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sci Transl Med. 2014 Jul 30;6(247):247ra102</RefSource><PMID Version="1">25080477</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Microbiol Rev. 2009 Jan;22(1):13-36, Table of Contents</RefSource><PMID Version="1">19136431</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Aug 15;175(4):2510-6</RefSource><PMID Version="1">16081823</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2013 Jul 15;191(2):795-809</RefSource><PMID Version="1">23776179</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2010 Nov;78(11):4625-33</RefSource><PMID Version="1">20732997</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Chem. 2007 Jul;53(7):1244-53</RefSource><PMID Version="1">17510307</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2009 Mar;77(3):1165-74</RefSource><PMID Version="1">19139189</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5108-13</RefSource><PMID Version="1">15792998</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2008 Jan;118(1):342-51</RefSource><PMID Version="1">18064303</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2014 Mar 1;209(5):789-98</RefSource><PMID Version="1">24133188</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4438-47</RefSource><PMID Version="1">26216993</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunol Res. 2009;43(1-3):85-97</RefSource><PMID Version="1">18810335</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2001 Jul;69(7):4390-7</RefSource><PMID Version="1">11401978</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000913" MajorTopicYN="N">Antibodies, Protozoan</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000917" MajorTopicYN="N">Antibody Formation</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000953" MajorTopicYN="N">Antigens, Protozoan</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007109" MajorTopicYN="Y">Immunity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008288" MajorTopicYN="N">Malaria</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D052940" MajorTopicYN="N">Merozoites</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018512" MajorTopicYN="N">Parasitemia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">P. falciparum</Keyword><Keyword MajorTopicYN="N">children</Keyword><Keyword MajorTopicYN="N">serosurveillance</Keyword><Keyword MajorTopicYN="N">vaccines</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>09</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2018</Year><Month>04</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27837017</ArticleId><ArticleId IdType="pii">jlb.5MA0716-294R</ArticleId><ArticleId IdType="doi">10.1189/jlb.5MA0716-294R</ArticleId><ArticleId IdType="pmc">PMC5346181</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E85 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000E85 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:27837017
|texte= Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27837017" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |